Clinical and Histopathologic Study of Apocrine-Type Mixed Tumor of the Skin

Author:

Ishihara Yuri1,Ogita Azusa1,Ito Keigo1,Saeki Hidehisa2,Ansai Shin-ichi1

Affiliation:

1. Division of Dermatology and Dermatopathology, Nippon Medical School Musashi Kosugi Hospital, Kanagawa, Japan; and

2. Division of Dermatology, Nippon Medical School, Tokyo, Japan.

Abstract

Abstract: Mixed tumor of the skin (MTS) is a tumor characterized by folliculosebaceous–apocrine differentiation. Because of the wide range of histological variations, understanding the unique features of MTS can help improve diagnosis. This study describes the histopathological characteristics of MTS, mainly apocrine-type MTS (AMT), using 166 cases of AMT. We found that nodular aggregates of myoepithelial cells, mucinous changes in the stroma, and follicular differentiation were standard characteristic features of MTS. Among the cases studied, 67% showed prominent follicular germinative cells and 40% showed prominent lipomatous metaplasia in the stroma. These cases often pose difficulties for the diagnosis of AMT because of insufficient evidence of sweat glands or myoepithelial cell differentiation. This is the first study to examine how the histological features of AMT change as the tumor extends deeper into the dermis. We found that the proportion of AMT with folliculosebaceous differentiation and large lumina increased as it got deeper into the dermis. Histopathological diagnosis of MTS is vital because the clinical symptoms lack specificity. This study enhances our understanding of the histopathological characteristics of MTS.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Dermatology,General Medicine,Pathology and Forensic Medicine

Reference11 articles.

1. Chondroid syringoma. Mixed tumor of skin, salivary gland type;Hirsch;Arch Dermatol,1961

2. Mixed tumors of skin: eccrine and apocrine types;Heading;Arch Dermatol.,1961

3. Skin adnexal neoplasms—part 1: an approach to tumours of the pilosebaceous unit;Alsaad;J Clin Pathol.,2007

4. Skin adnexal neoplasms—part 2: an approach to tumours of cutaneous sweat glands;Obaidat;J Clin Pathol.,2007

5. The histopathological analysis of 18 cases of mixed tumor of the skin;Murasawa;Jpn J Clin Dermatol.,2002

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3