Signet-Ring Cell/Histiocytoid Carcinoma: Report of Two Cases and Systematic Review of the Literature on the Epidemiology, Clinical Characteristics, and Pathological and Molecular Findings-Reference-Cited by-同舟云学术

Signet-Ring Cell/Histiocytoid Carcinoma: Report of Two Cases and Systematic Review of the Literature on the Epidemiology, Clinical Characteristics, and Pathological and Molecular Findings

Published:2023-07-28 Issue:9 Volume:45 Page:626-630
ISSN:0193-1091
Container-title:The American Journal of Dermatopathology
language:en
Short-container-title:

Author:

Michalek Irmina Maria¹²^ORCID,Caetano dos Santos Florentino Luciano²^ORCID,Zwolinski Jakub³,Olszewski Wojciech¹,Gałazka Adam³,Prochorec-Sobieszek Monika¹^ORCID,Durzynska Monika¹^ORCID

Affiliation:

1. Department of Pathology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland;

2. Harvard Business School, Harvard, Boston, MA; and

3. Head and Neck Cancer Department, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.

Abstract

Abstract: Signet-ring cell/histiocytoid carcinoma (SRCHC) is a rare appendageal tumor, mainly considering eyelids, more rarely axillae. This article describes 2 novel SRCHC cases of 71- and 66-year-old men and systematically reviews the literature on SRCHC. Of all cases reported in the literature, 73 (91.2%) were men and 7 (8.8%) were women. The median age at diagnosis was 71 years. Skin changes were located in the eyelids (68%) and axillae (32%). In all tested cases, SRCHC cells expressed CK7, CKAE1/AE3, EMA, CAM5.2, and AR and PIK3CA mutations. Future research should determine whether AR/PIK3CA-targeted therapies influence patients' survival.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Dermatology,General Medicine,Pathology and Forensic Medicine

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