Connexin 43 in Dermatofibroma and Dermatofibrosarcoma Protuberans: Diagnostic, Pathogenic, and Therapeutic Implications-Reference-Cited by-同舟云学术

Connexin 43 in Dermatofibroma and Dermatofibrosarcoma Protuberans: Diagnostic, Pathogenic, and Therapeutic Implications

Published:2023-10-02 Issue:12 Volume:45 Page:812-815
ISSN:0193-1091
Container-title:The American Journal of Dermatopathology
language:en
Short-container-title:

Author:

Fernandez-Flores Angel¹²^ORCID,Varela-Vazquez Adrian³,Mayan Maria D.³,Fonseca Eduardo³⁴

Affiliation:

1. Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain;

2. Department of Cellular Pathology, Hospital de la Reina, Ponferrada, Spain;

3. Department of Research, Institute for Biomedical Research of A Coruña (INIBIC), University of A Coruña (UDC), A Coruña, Spain; and

4. Department of Dermatology, Universitary Hospital of A Coruña, A Coruña, Spain.

Abstract

Abstract: Connexins play a crucial role in the formation of gap junctions that connect cells to each other, as well as cells to the surrounding environment. In recent years, connexin 43 has been extensively studied in various human tumors. In this study, we conducted an immunohistochemical analysis to evaluate the expression of connexin in 16 dermatofibromas (DFs) and 13 dermatofibrosarcoma protuberans (DFSP). Connexin was diffusely expressed in the cytoplasm of all DFs with moderate or strong intensity, whereas all DFSPs showed negative staining. In addition to its diagnostic implications, the loss of Cx43 may elucidate the invasive capacity of DFSP and offer a potential avenue for future therapeutic interventions.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Dermatology,General Medicine,Pathology and Forensic Medicine

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