Immunohistochemical Analysis of Lymphocyte Populations in Acute Skin Rejection: The University Health Network Addition to the Banff Classification-Reference-Cited by-同舟云学术

Immunohistochemical Analysis of Lymphocyte Populations in Acute Skin Rejection: The University Health Network Addition to the Banff Classification

Published:2023-03 Issue:3 Volume:11 Page:e4831
ISSN:2169-7574
Container-title:Plastic and Reconstructive Surgery - Global Open
language:en
Short-container-title:

Author:

Haykal Siba¹²³,Barone Natasha³,Rostami Sara¹,Moshkelgosha Sajad¹,Juvet Stephen¹,Keshavjee Shaf¹,Ghazarian Danny⁴

Affiliation:

1. Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, Department of Surgery, University Health Network, University of Toronto, Toronto, ON, Canada

2. Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada

3. Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada

4. Department of Pathology, University Health Network, University of Toronto, Toronto, ON, Canada.

Abstract

Background:Acute rejection in vascularized composite allotransplantation has been identified using the Banff 2007 working classification. We propose an addition to this classification based on histological and immunological assessment within the skin and subcutaneous tissue.Methods:Biopsies from vascularized composite transplant patients were obtained at scheduled visits and whenever skin changes occurred. Histology and immunohistochemistry were performed on all samples, looking at infiltrating cells.Results:Observations were made specifically related to each component of the skin, including the epidermis, dermis, vessels, and subcutaneous tissue. Our findings led to the establishment of the University Health Network addition of skin rejection.Conclusions:The high rate of rejection where the skin is involved requires novel techniques for early detection. The University Health Network skin rejection addition can serve as an adjunct to the Banff classification.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Surgery,General Medicine

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