The Associations of Genetic Variants in E-cadherin Gene With Clinical Outcome of Epithelial Ovarian Cancer

Abstract

ObjectiveThe E-cadherin protein plays major roles in tumor progression, invasion, and metastasis. Polymorphisms located in the E-cadherin gene (CDH1) may contribute to increased risks of specific cancers. In this study, we evaluated the associations between genetic variants inCDH1and the clinical outcomes of patients with epithelial ovarian cancer (EOC).Materials and MethodsWe assessed the−160C/Aand−347G/GApolymorphisms in the promoter region, as well as the3′-UTR +54C/Tpolymorphism of E-cadherin, in 257 patients with EOC by ligase detection reaction–polymerase chain reaction.ResultsMultivariate analysis showed that patients with EOC with theCDH1 −347GA/GAgenotype had shorter progression-free survival and overall survival (hazard ratio [HR], 2.16; 95% confidence interval [CI], 1.06–4.40 and HR, 2.06; 95% CI, 1.01–4.19, respectively) compared to those carrying the G/G genotype. Likewise, the patients with theCDH1 −160A/Agenotype had a shorter progression-free survival than those with the C/C genotype (HR, 4.12; 95% CI, 1.43–111.88). No significant association was detected between theCDH1 3′-UTR +54C/Tpolymorphism and survival of the patients with EOC.ConclusionsTheCDH1 −347GA/GAand−160A/Agenotypes may be prognostic markers that can help to identify patients at increased risk of invasive/metastatic cancer in northern China.