Subtherapeutic Exposure of Ganciclovir in Children Despite Appropriate Dosing: A Short Communication

Author:

Marfil Sjanene1,Märtson Anne-Grete12ORCID,Toren-Wielema Marlous1,Leer-Buter Coretta3,Schölvinck Elisabeth H.4,Alffenaar Jan-Willem C.567,Touw Daan J.1,Sturkenboom Marieke G. G.1

Affiliation:

1. Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands;

2. University of Liverpool, Antimicrobial Pharmacodynamics and Therapeutics, Liverpool, United Kingdom;

3. University of Groningen, University Medical Center Groningen, Groningen, Department of Medical Microbiology and Infection Prevention ;

4. University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Infectious Diseases, Groningen, the Netherlands;

5. Sydney Institute of Infectious Diseases, the University of Sydney, Westmead ;

6. The University of Sydney, Sydney Pharmacy School, Faculty of Medicine and Health, Camperdown; and

7. Department of Pharmacy, Westmead Hospital, Westmead, Australia.

Abstract

Abstract: Therapeutic drug monitoring (TDM) results for ganciclovir in 12 different treatment episodes showed large intraindividual and interindividual variabilities in the trough concentration and area under the 24-hour concentration–time curve (AUC24). Despite adequate valganciclovir dosing, subtherapeutic concentrations were found in 30% of the treatment episodes. A decrease in viral load was observed regardless of subtherapeutic exposure. These findings show the need for target concentration evaluation and assessment of the applicability of ganciclovir TDM in children.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Pharmacology (medical),Pharmacology

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