Rethinking Sjögren Beyond Inflammation: Considering the Role of Nerves in Driving Disease Manifestations

Author:

Sanchez Victor,Dobzinski Noa,Fox Robert,Galor AnatORCID

Abstract

Abstract: Sjögren syndrome (SS) is a chronic inflammatory autoimmune disease characterized by destruction of mucosal glands resulting in dry eye and dry mouth. Ocular presentations can be heterogenous in SS with corneal nerves abnormalities that are structural, functional, or both. Some individuals present with corneal hyposensitivity, with a phenotype of decreased tear production and epithelial disruption. Others present with corneal hypersensitivity, with a phenotype of neuropathic pain including light sensitivity and pain out of proportion to signs of tear dysfunction. A similar correlate can be found outside the eye, with dry mouth predominating in some individuals while pain conditions predominate in others. Understanding how nerve status affects SS phenotype is an important first step to improving disease management by targeting nerve abnormalities, as well as inflammation.

Funder

Sjogrens Foundation Pilot Research Grant

Office of Research and Development, Clinical Sciences R&D

Office of Research and Development Biomedical Laboratory R&D (BLRD) Service

Office of Research and Development Rehabilitation R&D

Department of Defense Gulf War Illness Research Program

Vision Research Program

National Eye Institute U01

NIH Center Core Grant

Research to Prevent Blindness Unrestricted Grant

Publisher

Ovid Technologies (Wolters Kluwer Health)

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