Post-Acute Myocardial Infarction Heart Failure Core Genes and Relevant Signaling Pathways

Author:

Lin Ling1,Zicheng Ling2,Shaohua Gu3

Affiliation:

1. Department of Cardiovascular Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China;

2. Department of Interal Medicine, Weiting Community Health Center of Suzhou Industrial Park, Suzhou, Jiangsu, China; and

3. Department of Nephrology, Kunshan Third Hospital, Suzhou, China.

Abstract

Abstract: There is increasing concern about heart failure after myocardial infarction and the current clinical treatment measures for ventricular remodeling. Herein, we present the results of differential gene analysis, pathway enrichment analysis, and characteristic gene screening. Our study identifies 4 core genes (KLRC2, SNORD105, SNORD45B, and RNU5A-1) associated with post-acute myocardial infarction (AMI) heart failure. The authors discuss the significance of the identified core genes, their potential implications in immune dysfunction and heart failure, and their relevance to disease regulatory genes. The study concludes by emphasizing the importance of clinical relevance in molecular research and suggests potential therapeutic targets for post-AMI heart failure.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Pharmacology

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3. Expert consensus on prevention and treatment of ventricular remodeling after acute myocardial infarction [J];Chin J Cardiovasc Dis,2020

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5. NCBI GEO: archive for functional genomics data sets—update;Barrett;Nucleic Acids Res,2012

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1. Molecular Insights on Ischemic Heart Failure: From Core Genes to Hearts;Journal of Cardiovascular Pharmacology;2023-12

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