In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction

Author:

Brandon Esther F. A.,Meijerman Irma,Klijn Joyce S.,Arend Dineke den,Sparidans Rolf W.,Lázaro Louis López,Beijnen Jos H.,Schellens Jan H. M.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cancer Research,Pharmacology (medical),Pharmacology,Oncology

Reference39 articles.

1. A clinical armamentarium of marine-derived anti-cancer compounds;Jimeno;Anticancer Drugs,2002

2. Progress in the acquisition of new marine-derived anticancer compounds: development of Ecteinascidin-743 (ET-743);Jimeno;Drugs Future,1996

3. Ecteinascidin (ET-743). Preclinical antitumor development of a marine derived natural product;Rinehart;Proc Am Soc Cancer Res,1995

4. Proc. 11th NCI–EORTC–AACR Symposium on New Drugs in Cancer Therapy;Zelek,2000

5. Ecteinascidin-743 (ET-743) induces durable responses and promising 1-year survival rates in soft tissue sarcomas (STS): final results of phase II and pharmacokinetic studies in the USA;Demetri;Proc Am Soc Clin Oncol,2001

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