Genetic and biochemical modulation of 5-fluorouracil through the overexpression of thymidine kinase: an in-vitro study

Author:

Fanciullino Raphaelle,Evrard Alexandre,Cuq Pierre,Giacometti Sarah,Peillard Laurent,Mercier Cédric,Aubert Claude,Milano Gérard,Ciccolini Joseph

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cancer Research,Pharmacology (medical),Pharmacology,Oncology

Reference39 articles.

1. Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells;Wang;Cancer Res,2004

2. Basis for natural variation in sensitivity to 5-fluorouracil in mouse and human cells in culture;Laskin;Cancer Res,1979

3. Relationship of dUMP and free FdUMP pools to inhibition of thymidylate synthase by 5-fluorouracil;Berger;Mol Pharmacol,1984

4. A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa;Peters;Cancer,1991

5. Uridine phosphorylase: an important enzyme in pyrimidine metabolism and fluoropyrimidine activation;Cao;Drugs Today (Barc),2004

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