Dynamic choice HIV prevention intervention at outpatient departments in rural Kenya and Uganda

Author:

Koss Catherine A.1,Ayieko James2,Kabami Jane3,Balzer Laura B.4,Kakande Elijah3,Sunday Helen3,Nyabuti Marilyn2,Wafula Erick5,Shade Starley B.1,Biira Edith3,Opel Fred2,Atuhaire Hellen N.3,Okochi Hideaki1,Ogachi Sabina2,Gandhi Monica1,Bacon Melanie C.6,Bukusi Elizabeth A.2,Chamie Gabriel1,Petersen Maya L.4,Kamya Moses R.7,Havlir Diane V.1,

Affiliation:

1. University of California San Francisco, San Francisco California, USA

2. Kenya Medical Research Institute, Kisumu, Kenya

3. Infectious Diseases Research Collaboration, Kampala, Uganda

4. University of California Berkeley, Berkeley, California, USA

5. Global Programs for Research and Training, Kisumu, Kenya

6. National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA

7. Makerere University College of Health Sciences, Kampala, Uganda.

Abstract

Objective: HIV prevention service delivery models that offer product choices, and the option to change preferences over time, may increase prevention coverage. Outpatient departments in sub-Saharan Africa diagnose a high proportion of new HIV infections, but are an understudied entry point to biomedical prevention. Design: Individually randomized trial of dynamic choice HIV prevention (DCP) intervention vs. standard-of-care (SOC) among individuals with current/anticipated HIV exposure risk at outpatient departments in rural Kenya and Uganda (SEARCH; NCT04810650). Methods: Our DCP intervention included 1) product choice (oral preexposure prophylaxis [PrEP] or postexposure prophylaxis [PEP]) with an option to switch over time, 2) HIV provider- or self-testing, 3) service location choice (community vs. clinic-based), and 4) provider training on patient-centered care. Primary outcome was proportion of follow-up covered by PrEP/PEP over 48 weeks assessed via self-report. Results: We enrolled 403 participants (61% women; median 27 years, IQR 22–37). In the DCP arm, 86% ever chose PrEP, 15% ever chose PEP over 48 weeks; selection of HIV self-testing increased from 26 to 51% and of out-of-facility visits from 8 to 52%. Among 376 of 403 (93%) with outcomes ascertained, time covered by PrEP/PEP was higher in DCP (47.5%) vs. SOC (18.3%); difference = 29.2% (95% confidence interval: 22.7–35.7; P < 0.001). Effects were similar among women and men (28.2 and 31.0% higher coverage in DCP, respectively) and larger during periods of self-reported HIV risk (DCP 64.9% vs. SOC 26.3%; difference = 38.6%; 95% confidence interval: 31.0–46.2; P < 0.001). Conclusion: A dynamic choice HIV prevention intervention resulted in two-fold greater time covered by biomedical prevention products compared to SOC in general outpatient departments in eastern Africa.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Immunology,Immunology and Allergy

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