Coronavirus disease 2019 outcomes in a population-based cohort of people with HIV and a matched cohort of people without HIV during Omicron variant waves

Author:

Chambers Catharine12,Cooper Curtis L.3,Kroch Abigail E.245,Buchan Sarah A.256,Kendall Claire E.678,Kwong Jeffrey C.256910,Moideddin Rahim29,Nguyen Lena6,Arbess Gordon911,Benoit Anita C.21213,Costiniuk Cecilia T.14,Habanyama Muluba15,Janjua Naveed Z.1617,Langlois Marc-André18,McCullagh John19,Mbuagbaw Lawrence2021222324,Moqueet Nasheed25,Nambiar Devan26,Rueda Sergio2728,Samji Hasina1629,Tran Vanessa530,Walmsley Sharon10,Anis Aslam1517,Burchell Ann N.129

Affiliation:

1. MAP Centre for Urban Health Solutions, Unity Health Toronto

2. Dalla Lana School of Public Health, University of Toronto, Toronto

3. Ottawa Hospital Research Institute, Ottawa

4. Ontario HIV Treatment Network

5. Public Health Ontario

6. ICES, Toronto

7. Bruyère Research Institute

8. Department of Family Medicine, Faculty of Medicine, University of Ottawa, Ottawa

9. Department of Family and Community Medicine, Temerty Faculty of Medicine

10. Department of Medicine, University Health Network

11. Department of Family and Community Medicine, Unity Health Toronto, Toronto

12. Department of Health and Society, University of Toronto Scarborough, Scarborough

13. Women's College Research Institute, Women's College Hospital, Toronto, Ontario

14. Research Institute of the McGill University Health Centre, Montreal, Quebec

15. CIHR Canadian HIV Trials Network

16. BC Centre for Disease Control

17. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia

18. Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa

19. HQ Health Hub, Toronto

20. Department of Health Research Methods, Evidence and Impact

21. Department of Anesthesia

22. Department of Pediatrics, McMaster University

23. Biostatistics Unit, Father Sean O'Sullivan Research Centre, St Joseph's Healthcare, Hamilton, Ontario, Canada

24. Centre for Development of Best Practices in Health (CDBPH), Yaoundé Central Hospital, Yaoundé, Cameroon

25. Public Health Agency of Canada, Ottawa

26. Gay Men's Sexual Health Alliance

27. Centre for Addiction and Mental Health

28. Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario

29. Simon Fraser University, Burnaby, British Columbia

30. Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Abstract

We found that rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing and reverse transcriptase (RT)-PCR-confirmed infection were approximately 50% higher in a population-based cohort of people with HIV compared with a matched cohort of people without HIV during the Omicron era (2 January 2022 to 31 March 2023) in Ontario, Canada, after controlling for age, sex, residential census tract, and country of birth. Rates of coronavirus disease 2019 (COVID-19)-related hospitalization and/or death were more than double. Differences persisted independent of vaccination, healthcare access, and COVID-19 diagnosis.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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