Targeting B cells for treatment of systemic sclerosis

Author:

Terui Hitoshi,Segawa Yuichiro,Asano Yoshihide

Abstract

Purpose of review The pathogenesis of systemic sclerosis (SSc) has been linked to dysfunctional B cells as demonstrated in previous research. This review aims to show the evidence and ongoing clinical trials of B cell-targeted therapy and overview the various aspects of B cell involvement in SSc. Recent findings We provide an overview of the current understanding and therapeutic strategies targeting B cells in SSc patients. Several molecular targets of B cells have been identified for treating SSc, including CD20, CD19, B-cell activating factor (BAFF), and proteasome. Summary Many clinical trials have demonstrated that B cells play a critical role in the pathogenesis of SSc and may be a potential therapeutic target to improve disease symptoms. Although large-scale clinical studies are needed, various B cell-targeted therapies have the potential to address the unmet needs of SSc patients.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Rheumatology

Reference55 articles.

1. Systemic sclerosis;Allanore;Nat Rev Dis Primers,2015

2. Systemic sclerosis;Asano;J Dermatol,2018

3. Systemic sclerosis;Denton;Lancet,2017

4. B cell infiltration in systemic sclerosis-associated interstitial lung disease;Lafyatis;Arthritis Rheum,2007

5. Systemic and cell type-specific gene expression patterns in scleroderma skin;Whitfield;Proc Natl Acad Sci,2003

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