Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity

Author:

Roberts Rebecca L.,Gearry Richard B.,Bland Michael V.,Sies Christiaan W.,George Peter M.,Burt Michael,Marinaki Anthony M.,Arenas Monica,Barclay Murray L.,Kennedy Martin A.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Genetics(clinical),Genetics,Molecular Biology,Molecular Medicine,General Pharmacology, Toxicology and Pharmaceutics

Reference18 articles.

1. Thiopurine S-methyltransferase pharmacogenetics: insights, challenges and future directions;Wang;Oncogene,2006

2. Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants;Schaeffeler;Pharmacogenetics,2004

3. Segregation analysis of human red blood cell thiopurine methyltransferase activity;Vuchetich;Genet Epidemiol,1995

4. Characterization of a variable number tandem repeat region in the thiopurine S-methyltransferase gene promoter;Spire-Vayron de la Moureyre;Pharmacogenetics,1999

5. Measurement of thiopurine methyl transferase activity guides dose-initiation and prevents toxicity from azathioprine;Sies;N Z Med J,2005

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