Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants-Reference-Cited by-同舟云学术

Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants

Published:2012-12 Issue:12 Volume:22 Page:858-867
ISSN:1744-6872
Container-title:Pharmacogenetics and Genomics
language:en
Short-container-title:

Author:

Holzinger Emily R.,Grady Benjamin,Ritchie Marylyn D.,Ribaudo Heather J.,Acosta Edward P.,Morse Gene D.,Gulick Roy M.,Robbins Gregory K.,Clifford David B.,Daar Eric S.,McLaren Paul,Haas David W.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Genetics (clinical),Genetics,Molecular Biology,Molecular Medicine,General Pharmacology, Toxicology and Pharmaceutics

Reference34 articles.

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3. The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIVAIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity.;Ward;J Pharmacol Exp Ther,2003

4. Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study.;Haas;AIDS,2004

5. Homozygous CYP2B6 6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens.;Tsuchiya;Biochem Biophys Res Commun,2004

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