Neurocognitive Functions After 6-Month Buprenorphine (Naloxone)–Based Opioid Agonist Maintenance Treatment

Author:

Ghosh Abhishek1,Shaktan Alka1,Nehra Ritu2,Verma Abhishek,Rana Devender K.1,Ahuja Chirag K.3,Modi Manish4,Singh Paramjit3,Basu Debasish1

Affiliation:

1. Drug Deaddiction and Treatment Centre, Department of Psychiatry

2. Department of Psychiatry, Postgraduate Institute of Medical Education and Research

3. Radiodiagnosis & Imaging

4. Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Abstract

Abstract Background Medications for opioid use disorder (OUD) may influence neurocognitive functions. Inadequate power, confounders, and practice effects limit the validity of the existing research. We examined the change in cognitive functions in patients with OUD at 6-month buprenorphine (naloxone) posttreatment and compared the cognitive performance of the buprenorphine-treated group with control subjects. Methods We recruited 498 patients with OUD within a week of initiating buprenorphine. Assessments were done twice—at baseline and 6 months. Those abstinent from illicit opioids and adherent to treatment (n = 199) underwent follow-up assessments. Ninety-eight non–substance-using control subjects were recruited from the community. The neurocognitive assessments comprised the Wisconsin Card Sorting Test, Iowa Gambling Task, Trail-Making Tests A and B (TMT-A and TMT-B), and verbal and visual N-Back Test. We controlled for potential effect modifiers. Results Twenty-five of the 32 test parameters significantly improved with 6 months of buprenorphine treatment; 20 parameters withstood corrections for multiple comparisons (P < 0.001). The improved test domains spread across cognitive tests: Wisconsin Card Sorting Test (perseverative errors and response, categories completed, conceptual responses), TMTs (time to complete), verbal and visual N-Back Tests (hits, omission, and total errors). After treatment, OUD (vs control subjects) had less perseverative response and error (P < 0.001) and higher conceptual response (P = 0.004) and took lesser time to complete TMT-A (P < 0.001) and TMT-B (P = 0.005). The baseline neurocognitive functions did not differ between those who retained and those who discontinued the treatment. Conclusion Cognitive functions improve in patients with OUD on buprenorphine. This improvement is unlikely to be accounted for by the practice effect, selective attrition, and potential confounders.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Reference48 articles.

1. Neuropsychological consequences of chronic opioid use: a quantitative review and meta-analysis;Neurosci Biobehav Rev,2012

2. Neuropsychological functioning in opioid use disorder: a research synthesis and meta-analysis;Am J Drug Alcohol Abuse,2019

3. Quality of life as an outcome of opioid use disorder treatment: a systematic review;J Subst Abuse Treat,2017

4. Addiction and cognition;Addict Sci Clin Pract,2010

5. Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence;Cochrane Database Syst Rev,2014

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3