Regional White Matter Hyperintensities Relate to Specific Cognitive Abilities in Older Adults Without Dementia

Author:

Membreno Rachel1,Thomas Kelsey R.23,Calcetas Amanda T.3,Edwards Lauren4,Bordyug Maria3,Showell Maya2,Stanfill Morgan2,Brenner Einat K.3,Walker Kayla S.1,Rotblatt Lindsay J.53,Brickman Adam M.678,Edmonds Emily C.910,Bangen Katherine J.23,

Affiliation:

1. Department of Psychology, San Diego State University

2. Research Service, VA San Diego Healthcare System

3. Department of Psychiatry, University of California San Diego

4. San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA

5. Psychology Service, VA San Diego Healthcare System

6. Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University

7. Gertrude H. Sergievsky Center, Columbia University

8. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY

9. Banner Alzheimer’s Institute

10. Department of Psychology, University of Arizona, Tucson, AZ

Abstract

Introduction: White matter hyperintensities (WMHs) are magnetic resonance imaging markers of small vessel cerebrovascular disease that are associated with cognitive decline and clinical Alzheimer disease. Previous studies have often focused on global or total WMH; less is known about associations of regional WMHs and cognitive abilities among older adults without dementia. Methods: A total of 610 older adults with normal cognition (n=302) or mild cognitive impairment (n=308) from the Alzheimer’s Disease Neuroimaging Initiative underwent neuropsychological testing and magnetic resonance imaging. Linear regression models examined associations between regional WMH volumes and cognition, adjusting for age, sex, education, apolipoprotein E ε4 allele frequency, and pulse pressure. Results: Among all participants, greater regional WMH volume in all lobes was associated with poorer performance on memory and speed/executive functioning. Among participants with normal cognition, greater temporal and occipital WMH volumes were associated with poorer memory, whereas no regional WMH volumes were associated with speed/executive function. Discussion: Results show that greater regional WMH volume relates to poorer cognitive functioning—even among those with normal cognition. Together with results from previous studies, our findings raise the possibility that WMH may be a useful therapeutic target and/or important effect modifier in treatment or prevention dementia trials.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Gerontology,Clinical Psychology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The Spectrum of Cerebral Small Vessel Disease;Neurologic Clinics;2024-08

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