Focusing on Earlier Management of Alzheimer Disease

Author:

Frederiksen Kristian Steen12,Morató Xavier34,Zetterberg Henrik56789,Gauthier Serge1011,Boada Mercè3412,Pytel Vanesa34,Mattke Soeren13

Affiliation:

1. Danish Dementia Research Centre, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

2. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

3. Ace Alzheimer Center Barcelona, Spain

4. Universitat International de Catalunya-Barcelona, Spain

5. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden

6. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden

7. Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK

8. UK Dementia Research Institute at University College London, London, UK

9. Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong

10. AD and Related Disorders Research Unit, McGill Center for Studies in Aging, Verdun, Quebec, Canada

11. Departments of Neurology & Neurosurgery, Psychiatry, and Medicine at McGill, Montréal (Québec), Canada

12. Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain

13. Center for Improving Chronic Illness Care at the University of Southern California, San Diego, CA

Abstract

Background: Despite the number of people living with Alzheimer disease (AD), awareness of the early stages of this condition, including mild cognitive impairment due to AD—which poses management challenges—continues to be low. To identify areas for improvement in early AD management, dementia specialists convened in a virtual roundtable meeting. Methodology: A modified version of the nominal group technique was followed to prioritize specific topics and allow experts to provide their opinions. The overarching topics prioritized and discussed were (1) education and support for primary care physicians on cognitive assessment, detection of mild cognitive impairment, and patient monitoring; (2) nonpharmacological interventions; (3) and the introduction of disease-modifying therapies. Conclusions: Consensus was achieved regarding the need for educating primary care physicians on identifying people with cognitive impairment and for better diagnostic tools for its detection and early management. Management of mild cognitive impairment due to AD should encompass an adequate follow-up schedule aiming to maintain function for as long as possible, and primary care physicians and patients should be aware of the benefits of nonpharmacological interventions.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Reference27 articles.

1. Clinical trial endpoints and their clinical meaningfulness in early stages of Alzheimer’s Disease;Cohen;J Prev Alzheimers Dis,2022

2. Global estimates on the number of persons across the Alzheimer’s disease continuum;Gustavsson;Alzheimers Dement,2023

3. Observational study of patient characteristics associated with a timely diagnosis of dementia and mild cognitive impairment without dementia;White;J Gen Intern Med,2022

4. Expected and diagnosed rates of mild cognitive impairment and dementia in the U.S. Medicare population: Observational analysis;Mattke;Alzheimers Res Ther,2023

5. How to use the nominal group and Delphi techniques;McMillan;Int J Clin Pharm,2016

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3