PHES scores have limited impact on the risk of overt HE in patients with minimal HE-Reference-Cited by-同舟云学术

PHES scores have limited impact on the risk of overt HE in patients with minimal HE

Published:2024-05 Issue:5 Volume:8 Page:
ISSN:2471-254X
Container-title:Hepatology Communications
language:en
Short-container-title:

Author:

Gairing Simon Johannes¹²^ORCID,Mangini Chiara³,Zarantonello Lisa³,Jonasson Elise⁴,Danneberg Sven⁵,Sultanik Philippe⁶,Galle Peter Robert¹²,Gioia Stefania⁷,Labenz Joachim⁸,Lok Anna S.⁹,Marquardt Jens Uwe⁵,Lauridsen Mette Munk⁴,Bloom Patricia P.⁹,Thabut Dominique⁶,Nardelli Silvia⁷,Montagnese Sara³¹⁰,Labenz Christian¹²^ORCID

Affiliation:

1. Department of Internal Medicine I, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany

2. Cirrhosis Center Mainz (CCM), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany

3. Department of Medicine, University of Padova, Padova, Italy

4. Department of Gastroenterology and Hepatology, Hospital of South West Jutland, Esbjerg, Denmark

5. Department of Medicine I, University Hospital Schleswig-Holstein, Lübeck, Germany

6. Service d’hépato-gastroentérologie, Sorbonne Université, Hôpital Pitié-Salpêtrière Assistance Publique Hôpitaux de Paris, Paris, France

7. Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

8. Department of Medicine, Diakonie Hospital Jung-Stilling, Siegen, Germany

9. Department of Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA

10. Chronobiology Section, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK

Abstract

Background: Minimal hepatic encephalopathy, defined by the portosystemic hepatic encephalopathy score (PHES), is associated with a higher risk of subsequent OHE. It remains unclear if there is a stepwise increase in OHE risk with worse PHES results. Methods: In this multicenter study, patients with minimal hepatic encephalopathy, as defined by abnormal PHES, were followed for OHE development. Results: In all, 207 patients were included. There was no stepwise increase in OHE risk with worse PHES results. Conclusions: Abnormal PHES is associated with a higher OHE risk, but we found no stepwise increase in OHE risk with worse PHES results below the established cutoff.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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