HIV Viral Load Scale-up Among Children and Adolescents: Trends in Viral Load Suppression, Sample Type and Processing in 7 PEPFAR Countries, 2015

HIV Viral Load Scale-up Among Children and Adolescents: Trends in Viral Load Suppression, Sample Type and Processing in 7 PEPFAR Countries, 2015–2018

Published:2023-01-18 Issue:4 Volume:42 Page:e102-e104
ISSN:0891-3668
Container-title:Pediatric Infectious Disease Journal
language:en
Short-container-title:

Author:

Hrapcak Susan¹^ORCID,Pals Sherri¹,Itoh Megumi¹,Peters Natalie²,Carpenter Deborah¹,Hackett Stephanie¹,Prao Aka K.³,Adje-Toure Christiane³,Eboi Ehui⁴,Mutisya Immaculate³,Nyabiage Omoto Lennah³,Ondondo Raphael O.³,Bowen Nancy⁵,Nyanya Winifred⁵,Kayira Dumbani³,Kaba Muluken D.³,Mwenda Rueben⁶,Deus Maria Ines³,Almeida Jose³,Cuco Rosa Marlene M.⁷,Boylan Ashley³,Beard Suzanne³,Ashikoto Sylvia⁵,van Rooyen Gerhard⁸,Kindra Gurpreet³,Diallo Karidia³,Carmona Sergio⁹,Nazziwa Esther³,Mwangi Christina³,Ntale Jonathan³,Ssewanyana Isaac¹⁰,Nabadda Susan N.¹⁰,Nabukenya Miriam¹⁰,Ellenberger Dennis¹,Rivadeneira Emilia¹

Affiliation:

1. Division of Global HIV and Tuberculosis, Center for Global Health, Centers for Disease Control and Prevention (CDC)

2. Emory University of Medicine, Atlanta, Georgia

3. Division of Global HIV and Tuberculosis, Center for Global Health, CDC

4. HIV/AIDS Program (PNLS), Ministry of Health and Public Hygiene, Côte d’Ivoire, West Africa

5. Ministry of Health, Nairobi, Kenya

6. Ministry of Health, Lilongwe, Malawi

7. Ministry of Health (Ministerio da Saude- MISAU), Maputo, Mozambique

8. Namibia Institute of Pathology, Windhoek, Namibia

9. Ministry of Health, Johannesburg, South Africa

10. Ministry of Health, Kampala, Uganda.

Abstract

HIV-positive children and adolescents face gaps in viral load (VL) testing. To understand trends in pediatric/adolescent VL testing, 7 countries collected data from Laboratory Information Management Systems. Results showed increasing proportion of VL tests done through dried blood spot (DBS) and decreased sample rejection rates for DBS compared with plasma, supporting use of DBS VL when skilled phlebotomy is unavailable.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Microbiology (medical),Pediatrics, Perinatology and Child Health

Reference6 articles.

1. HIV viral load monitoring among patients receiving antiretroviral therapy— eight sub-Saharan Africa countries, 2013-2018.;Lecher;MMWR Morb Mortal Wkly Rep,2021

2. Achieving antiretroviral therapy uptake and viral suppression among children and adolescents living with HIV in the UNAIDS 90-90-90 era across six countries in Eastern and Southern Africa- lessons from the BIPAI network.;Bacha;JAIDS,2022

3. Routine viral load monitoring in HIV-infected infants and children in low- and middle-income countries: challenges and opportunities.;Arpadi;J Int AIDS Soc,2017

4. On the front line of HIV virological monitoring: barriers and facilitators from a provider perspective in resource-limited settings.;Rutstein;AIDS Care,2016

5. Point-of-care HIV viral load testing: an essential tool for a sustainable global HIV/AIDS response.;Drain;Clin Microbiol Rev,2019

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pediatric and adolescent HIV viral load coverage and suppression rates in the context of the COVID-19 pandemic in 12 PEPFAR-supported sub-Saharan African countries in 2019 and 2020;PLOS Global Public Health;2024-08-01

2. Revolutionizing HIV-1 Viral Load Monitoring in India: The Potential of Dried Blood Spot Analysis for Expanding Access and Improving Care;Healthcare;2024-02-06

3. Dried Blood Spots—A Platform for Therapeutic Drug Monitoring (TDM) and Drug/Disease Response Monitoring (DRM);European Journal of Drug Metabolism and Pharmacokinetics;2023-07-26