Circulating Activated Platelets in Children With Long Covid: A Case-Controlled Preliminary Observation-Reference-Cited by-同舟云学术

Circulating Activated Platelets in Children With Long Covid: A Case-Controlled Preliminary Observation

Published:2024-07-15 Issue: Volume: Page:
ISSN:0891-3668
Container-title:Pediatric Infectious Disease Journal
language:en
Short-container-title:

Author:

Buonsenso Danilo¹²^ORCID,Sorrentino Silvia³,Ferretti Antonietta³,Morello Rosa¹,Valentini Piero¹,Di Gennaro Leonardo³⁴,De Candia Erica³⁴

Affiliation:

1. From the Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

2. Centro di Salute Globale, Università Cattolica del Sacro Cuore, Rome, Italy

3. Dipartimento di Scienze di Laboratorio ed Ematologiche, Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

4. Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Facoltà di Medicina, Rome, Italy.

Abstract

We investigated if children with Long Covid (n=14) have activated platelets compared with healthy controls (n=14). Platelet activation and secretion markers were investigated by flow cytometry using MoAbs directed against P-selectin, CD63, and PAC-1 in quiescent platelets and in platelets stimulated with 10-µM adenosine diphosphate and 25-µM protease activated receptor 1-activating peptide. Circulating platelets of patients with Long Covid had significantly increased expression of the activation marker cytometry using MoAbs directed against P-selectin (P = 0.019).

Publisher

Ovid Technologies (Wolters Kluwer Health)

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