Safety and Efficacy of Ceftaroline in Neonates With Staphylococcal Late-onset Sepsis: A Case Series Analysis-Reference-Cited by-同舟云学术

Safety and Efficacy of Ceftaroline in Neonates With Staphylococcal Late-onset Sepsis: A Case Series Analysis

Published:2023-07-13 Issue:10 Volume:42 Page:888-892
ISSN:0891-3668
Container-title:Pediatric Infectious Disease Journal
language:en
Short-container-title:

Author:

Callies Arnaud¹^ORCID,Martin-Perceval Lise²,Crémet Lise³,Gély Lilas³,Ruellan Anne-Lise⁴,Verdier Marie-Clemence⁵⁶,Gregoire Matthieu⁴,Flamant Cyril¹,Guillouzouic Aurélie³,Prot-Labarthe Sonia⁷⁸,Butin Marine⁹¹⁰,Launay Elise²

Affiliation:

1. Department of Neonatalogy, Nantes University Hospital, Nantes, France

2. Department of Pediatrics and Pediatric Emergency, Nantes University Hospital, Nantes, France

3. Department of bacteriology, Nantes University Hospital, Nantes, France

4. Clinical Pharmacology Laboratory Department, Nantes University Hospital, Nantes, France

5. Department of Pharmacology, Univ Rennes, CHU Rennes, France

6. Inserm, EHESP, IRSET (Institut de recherche en sante, environnement et travail), Rennes, France

7. Department of pharmacy, Nantes University Hospital, Nantes, France

8. UMR-S 1123, Épidémiologie Clinique et Évaluation Économique Appliquées aux Populations Vulnérables (ECEVE), Inserm, Université Paris Cité, Paris, France

9. Team Pathogénie des Staphylocoques (StaPath), CIRI (Centre International de Recherche en Infectiologie), Inserm U1111, University Claude Bernard Lyon 1, CNRS, ENS Lyon, Lyon, France

10. Neonatal Intensive Care Unit, Lyon University Hospital, HFME, Lyon, France

Abstract

Treatment of late-onset neonatal staphylococcal sepsis is sometimes challenging with feared side effects of vancomycin, increasing minimal inhibitory concentrations and questions about catheter management. In case of failure, ceftaroline was administered as a compassionate treatment in 16 infants (gestational age of less than 32 weeks and less than 28 postnatal days), whose first-line treatment failed. We report 11 successes and no severe adverse drug reactions. Larger data are required to confirm these encouraging results.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Microbiology (medical),Pediatrics, Perinatology and Child Health

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