Pan-valvulitis in Children with Kawasaki Disease: A Case Report and Review of the Literature

Author:

Leon-Jimenez Pelayo1,Lorenzo-Martin Maria1,Tomatis-Souverbielle Cristiana12,Akoghlanian Shoghik3ORCID,Cripe Linda4ORCID,Ramilo Octavio25ORCID,Mejias Asuncion25ORCID

Affiliation:

1. From the Division of Infectious Diseases, Nationwide Children’s Hospital

2. Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children’s Hospital, The Ohio State University College of Medicine

3. Division of Pediatric Rheumatology

4. Division of Pediatric Cardiology, Nationwide Children’s Hospital, Columbus, Ohio

5. Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, Tennessee.

Abstract

We present a rare case of pan-valvular involvement in a 5-month-old female with Kawasaki disease shock syndrome despite early treatment with intravenous immunoglobulin and corticosteroids. She experienced a favorable outcome after the addition of infliximab, which was guided based on clinical, laboratory and echocardiogram findings, rather than recrudescence of fever, the most common indicator of intravenous immunoglobulin resistance.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Microbiology (medical),Pediatrics, Perinatology and Child Health

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