Boosting of Voriconazole Levels With Omeprazole, A CYP450 2C19 Inhibitor-Reference-Cited by-同舟云学术

Boosting of Voriconazole Levels With Omeprazole, A CYP450 2C19 Inhibitor

Published:2023-03-03 Issue:6 Volume:42 Page:485-488
ISSN:0891-3668
Container-title:Pediatric Infectious Disease Journal
language:en
Short-container-title:

Author:

Hsu Alice J.¹^ORCID,Lee Carlton K. K.¹,McAteer John²,Zhang Sean X.³,Tamma Pranita D.²

Affiliation:

1. Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, Maryland

2. Division of Pediatric Infectious Diseases, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland

3. Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland

Abstract

Children metabolize voriconazole faster than adults and require higher weight-based doses and more frequent administration to achieve therapeutic troughs. We report a case of a 4-year-old girl with disseminated fusariosis with persistently undetectable voriconazole troughs. Omeprazole was added as a CYP2C19-inhibitor to increase voriconazole concentrations. This case highlights the role of omeprazole for voriconazole boosting in a child.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Microbiology (medical),Pediatrics, Perinatology and Child Health

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