Microbiologic Epidemiology of Early-onset Sepsis in Neonates Born at ≥35 0/7 Weeks’ Gestation in Korea During 2009

Microbiologic Epidemiology of Early-onset Sepsis in Neonates Born at ≥35 0/7 Weeks’ Gestation in Korea During 2009–2018

Published:2023-06-15 Issue:8 Volume:42 Page:705-710
ISSN:0891-3668
Container-title:Pediatric Infectious Disease Journal
language:en
Short-container-title:

Author:

Yoon Yoonsun¹²^ORCID,So Hyejin³⁴^ORCID,Lee Joon Kee⁵^ORCID,Kim Dongsub⁶^ORCID,Jo Kyo Jin⁷^ORCID,Kim Hyun Ho⁸^ORCID,Kim Yoo-Jin⁵^ORCID,Lee Jina³^ORCID,Jo Dae Sun⁸^ORCID,Kim Yun-Kyung⁹^ORCID,Park Su Eun⁷^ORCID,Chang Yun Sil¹^ORCID,Kim Yae-Jean¹¹⁰^ORCID

Affiliation:

1. Department of Pediatrics, Samsung Medical Center, School of Medicine, Sungkyungwan University, Seoul, Korea

2. Department of Pediatrics, Korea University Guro Hospital, Seoul, Korea (current affiliation)

3. Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

4. Department of Pediatrics, Chungnam National University Sejong Hospital, Sejong, Korea (current affiliation)

5. Department of Pediatrics, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea

6. Department of Pediatrics, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea

7. Department of Pediatrics, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea

8. Department of Pediatrics, Jeonbuk National University Children’s Hospital, Jeonbuk National University, Jeonju, Korea

9. Department of Pediatrics, Korea University College of Medicine, Seoul, Korea

10. Samsung Advanced Institute for Health Sciences and Technology, Seoul, Korea

Abstract

Background: Sepsis within the first 3 days of life remains a leading cause of neonatal mortality and morbidity. However, few studies have addressed the epidemiology of sepsis in late preterm and term neonates, particularly in Asia. We aimed to estimate the epidemiology of early-onset sepsis (EOS) in neonates born at ≥35 0/7 weeks’ gestation in Korea. Methods: A retrospective study was conducted in neonates with proven EOS born at ≥35 0/7 weeks’ gestation from 2009 to 2018 at seven university hospitals. EOS was defined as identifying bacteria from a blood culture within 72 hours after birth. Results: A total of 51 neonates (0.36/1,000 live births) with EOS were identified. The median duration from birth to the first positive blood culture collection was 17 hours (range, 0.2–63.9). Among the 51 neonates, 32 (63%) patients were born by vaginal delivery. The median Apgar score was 8 (range, 2–9) at 1 minute and 9 (range, 4–10) at 5 minutes. The most common pathogen was group B Streptococcus (n = 21; 41.2%), followed by coagulase-negative staphylococci (n = 7; 13.7%) and Staphylococcus aureus (n = 5, 9.8%). Forty-six (90.2%) neonates were treated with antibiotics on the first day of symptom onset, and 34 (73.9%) neonates received susceptible antibiotics. The overall 14-day case-fatality rate was 11.8%. Conclusion: This is the first multicenter study on the epidemiology of proven EOS in neonates born at ≥35 0/7 weeks’ gestation and found that group B Streptococcus was the most common pathogen in Korea.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Microbiology (medical),Pediatrics, Perinatology and Child Health

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