Severe Impairment of T-cell Immunity and Pulmonary GvHD Are Major Risk Factors for Nontuberculous Mycobacterial Infection After Pediatric Allogeneic Hematopoietic Stem Cell Transplantation-Reference-Cited by-同舟云学术

Severe Impairment of T-cell Immunity and Pulmonary GvHD Are Major Risk Factors for Nontuberculous Mycobacterial Infection After Pediatric Allogeneic Hematopoietic Stem Cell Transplantation

Published:2024-05-07 Issue:9 Volume:43 Page:885-888
ISSN:0891-3668
Container-title:Pediatric Infectious Disease Journal
language:en
Short-container-title:

Author:

Ascunce Marina¹^ORCID,Coccolo Alejandra¹,Mozo Yasmina²^ORCID,Baquero-Artigao Fernando³⁴⁵⁶,Rodriguez-Molino Paula³⁴⁵⁶,Toro-Rueda Carlos⁷,García-Clemente Paloma⁷,Sánchez-Zapardiel Elena⁴⁸,López-Granados Eduardo⁴⁸⁹,Corral-Sánchez Dolores²,Bueno David²⁴,Sisinni Luisa²,Pérez-Martínez Antonio²⁴¹⁰,Calvo Cristina³⁴⁵⁶¹⁰,del Rosal Teresa³⁴⁵⁹^ORCID

Affiliation:

1. From the Pediatrics Department, La Paz University Hospital

2. Pediatric Hemato-Oncology Department, La Paz University Hospital

3. Pediatrics and Infectious Disease Department, La Paz University Hospital

4. Hospital La Paz Institute for Health Research (IdiPAZ)

5. Translational Research Network of Pediatric Infectious Diseases (RITIP)

6. Center for Biomedical Research Network on Infectious Diseases (CIBERINFEC), Carlos III Health Institute

7. Microbiology Department, La Paz University Hospital

8. Immunology Department, La Paz University Hospital

9. Center for Biomedical Research Network on Rare Diseases (CIBERER U767), Carlos III Health Institute

10. Universidad Autónoma de Madrid, Madrid, Spain.

Abstract

Hematopoietic stem cell transplant recipients are prone to infectious complications. Infections caused by nontuberculous mycobacteria have increased in adults but literature in children is scarce. We report 6 episodes of disseminated or pulmonary nontuberculous mycobacteria infection among 5 pediatric hematopoietic stem cell transplant recipients. All but one were caused by Mycobacterium avium complex. Four patients died, 2 related to nontuberculous mycobacteria infection.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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