The Value of the Second QuantiFERON-TB Gold-Plus Antigen Tube at Diagnosis and at Treatment Completion in Spanish Children With Tuberculosis

Author:

Soler-Garcia Aleix1,Gamell Anna1,Monsonís Manuel2,Korta-Murua José Javier34,Espiau María5,Rincón-López Elena6,Rodríguez-Molino Paula7,Pérez-Porcuna Tomàs89,Bustillo-Alonso Matilde10,Santiago Begoña61112,Tebruegge Marc131415,Noguera-Julian Antoni1121617ORCID,

Affiliation:

1. Malalties Infeccioses i Resposta Inflamatòria Sistèmica en Pediatria, Servei de Malalties Infeccioses i Patologia Importada, Institut de Recerca Pediàtrica Sant Joan de Déu, Barcelona, Spain

2. Servei de Microbiologia, Hospital Sant Joan de Déu, Barcelona, Spain

3. Servicio de Pediatría, Hospital Universitario Donostia-Instituto BioDonostia, Donostia Ospitalea, San Sebastián, Spain

4. Departamento de Pediatría, Facultad de Medicina, EHU-UPV, Donostia University Hospital Gipuzkoa Building, San Sebastian, Spain

5. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d’Hebron, Vall d’Hebron Research Institute, Barcelona, Spain

6. Paediatric Infectious Diseases Unit, Gregorio Marañón Mother and Child Hospital, Madrid, Spain

7. Pediatric Infectious and Tropical Diseases Department, Hospital Universitario La Paz, Madrid, Spain

8. Atenció Primària, Fundació Assistencial Mútua de Terrassa, Terrassa, Spain

9. Unitat de Salut Internacional, Departament de Pediatria, Fundació Recerca Hospital Universitari Mútua de Terassa, Universitat de Barcelona, Terrassa, Spain

10. Pediatrics Department, Miguel Servet University Hospital, Zaragoza, Spain

11. Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain

12. Red de Investigación Translacional en Infectología Pediátrica (RITIP), Madrid, Spain

13. Department of Paediatrics, Klinik Ottakring, Wiener Gesundheitsverbund, Vienna, Austria

14. Department of Paediatrics, Royal Children’s Hospital Melbourne, University of Melbourne, Melbourne, Australia

15. Department of Infection, Immunity & Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom

16. Departament de Cirurgia i Especialitats Medicoquirúrgiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain

17. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, Spain.

Abstract

We studied 295 children (tuberculosis disease, n = 159; latent tuberculosis infection, n = 136) with positive QuantiFERON-TB Gold-Plus assay results. No significant differences between first and second antigen tube interferon-gamma responses were detected, irrespective of patient and disease characteristics at diagnosis. Of patients with a repeat assay after treatment completion (n = 65), only 16.9% converted to negative results.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Microbiology (medical),Pediatrics, Perinatology and Child Health

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