Clinical Relevance of RSV and SARS-CoV-2 Coinfections in Infants and Young Children

Author:

Rodriguez-Fernandez Rosa12ORCID,González-Martínez Felipe12,Perez-Moreno Jimena12,González-Sánchez María Isabel12,Toledo del Castillo Blanca12,Mingueza de la Paz Irene1,Diaz Pozo Laura1,Mejias Asuncion3,Ramilo Octavio3

Affiliation:

1. Department of Pediatrics, Hospital Infantil Gregorio Marañón, Madrid, Spain

2. Instituto de investigacion sanitaria Gregorio Marañón (IISGM), Madrid, Spain

3. Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, Tennessee.

Abstract

We analyzed the frequency, clinical impact and severity of respiratory syncytial virus (RSV) and SARS-CoV-2 coinfections in a single pediatric center between March 2020 and January 2023. Compared to single RSV infections, RSV/SARS-CoV-2 coinfections were uncommon (2.1%), occurred more frequently during circulation of omicron, and were associated with increased disease severity as defined by longer hospitalization and increased need for high-flow nasal cannula.

Funder

Fondo de investigacion sanitaria (FIS) del ISCIII

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Microbiology (medical),Pediatrics, Perinatology and Child Health

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