Delayed Induction of Noninflammatory SARS-CoV-2 Spike-Specific IgG4 Antibodies Detected 1 Year After BNT162b2 Vaccination in Children-Reference-Cited by-同舟云学术

Delayed Induction of Noninflammatory SARS-CoV-2 Spike-Specific IgG4 Antibodies Detected 1 Year After BNT162b2 Vaccination in Children

Published:2024-07-30 Issue: Volume: Page:
ISSN:0891-3668
Container-title:Pediatric Infectious Disease Journal
language:en
Short-container-title:

Author:

Kobbe Robin¹²³^ORCID,Rau Cornelius¹²,Schulze-Sturm Ulf⁴,Stahl Felix⁵,Fonseca-Brito Luis⁵,Diemert Anke⁶⁷,Lütgehetmann Marc⁷,Addo Marylyn M.¹⁸³,Arck Petra⁶⁷,Weskamm Leonie M.¹⁸³

Affiliation:

1. From the Institute for Infection Research and Vaccine Development

2. Department of Infectious Disease Epidemiology

3. German Centre for Infection Research, Hamburg, Germany.

4. Department of Pediatrics-Kinder-UKE

5. Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine

6. Institute of Immunology

7. Hamburg Center for Translational Immunology

8. Department for Clinical Immunology of Infectious Diseases, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany

Abstract

Humoral immune responses after BNT162b2 vaccination are predominantly composed of immunoglobulin (Ig) G1 and IgG3 subclass antibodies. As previously described in adults, S1-specific and receptor-binding domain–specific IgG4 levels increase significantly 1 year after the second BNT162b2 vaccination in children 5-11 years of age. Understanding mRNA vaccine–specific IgG4 responses in all age groups is crucial as more mRNA vaccines will reach licensure in the coming years.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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