Diagnostic Accuracy of Group A Streptococcus Rapid Antigen Detection Test on Middle Ear Fluid in Children With Acute Otitis Media With Spontaneous Perforation: A Prospective Multicenter Evaluation

Author:

Cohen Robert1234,Varon Emmanuelle5,Bidet Philippe67,Cohen Jérémie F.89,Béchet Stéphane14,Couloigner Vincent10,Michot Anne Sylvestre14,Guiheneuf Cécile4,Bonacorsi Stéphane67,Levy Corinne1234ORCID

Affiliation:

1. ACTIV, Association Clinique et Thérapeutique Infantile du Val-de-Marne, Créteil, France

2. Clinical Research Center (CRC), Centre Hospitalier Intercommunal de Créteil, Créteil, France

3. Université Paris Est, IMRB-GRC GEMINI, Créteil, France

4. AFPA, Association Française de Pédiatrie Ambulatoire, Orléans, France

5. Service de microbiologie, Hôpital Intercommunal de Créteil, Créteil, France

6. Université Paris Cité, IAME, INSERM, Paris, France

7. Service de microbiologie, Hôpital Robert-Debré, AP-HP, Paris, France

8. Department of General Pediatrics and Pediatric Infectious Diseases, Hôpital Necker-Enfants malades, AP-HP, Université Paris Cité, Paris, France

9. Centre of Research in Epidemiology and Statistics (Inserm UMR 1153), Université Paris Cité, Paris, France

10. Department of ENT, Hôpital Necker-Enfants malades, AP-HP, Université Paris Cité, Paris, France.

Abstract

Group A Streptococcus is one of the leading causes of otorrhea. The performance of rapid antigen tests in 256 children with otorrhea showed excellent sensitivity, 97.3% (95% confidence interval: 90.7%–99.7%), and specificity, 100% (95% confidence interval: 98.0%–100%). In a period of increasing invasive and noninvasive group A Streptococcus infections, an early diagnosis could be useful.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Microbiology (medical),Pediatrics, Perinatology and Child Health

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