First Evidence of Streptococcus pyogenes M1UK Clone in Pediatric Invasive Infections in Italy by Molecular Surveillance

Author:

Vrenna Gianluca12ORCID,Rossitto Martina13,Agosta Marilena4,Cortazzo Venere4,Fox Valeria1ORCID,De Luca Maia5,Lancella Laura5,Gargiullo Livia6,Granaglia Annarita4,Fini Vanessa4,Yu La Rosa Katia4,Argentieri Marta4,Pansani Laura4,Sisto Annamaria4,Raponi Massimiliano7,Villani Alberto8,Perno Carlo Federico4,Bernaschi Paola4

Affiliation:

1. From the Multimodal Laboratory Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

2. Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy

3. Major School in Microbiology and Virology, University Campus Bio-Medico, Rome, Italy

4. Microbiology and Diagnostic Immunology Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

5. Infectious Disease Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

6. General Pediatric and Infectious Disease Unit, Bambino Gesù Children’s Hospital, IRCSS, Rome, Italy

7. Medical Direction, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

8. General Pediatric and Infectious Disease Unit, Pediatric Emergency Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy.

Abstract

Invasive group A streptococci infections are increasing worldwide, mainly due to the emm1 lineage M1UK emergence. Although this variant has recently been described in adult Italian patients, its circulation in children has not yet been established. Characterizing by whole genome sequencing 6 invasive group A streptococci strains isolated between 2022 and 2023, we highlighted M1UK lineage circulation in pediatric patients in Italy.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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