Fetal Myocarditis Associated With Maternal SARS-CoV-2 Infection

Author:

Mannarino Savina1,Lanna Mariano23,Calcaterra Valeria45ORCID,Carzaniga Thomas6,Casiraghi Luca6,Lai Alessia7,Gabrieli Arianna7,Bergna Annalisa7,Fini Giulia1,Bianchi Silvia8,De Amici Mara9,Zehender Gianguglielmo7,Bellini Tommaso6,Buscaglia Marco6,Zuccotti Gianvincenzo57

Affiliation:

1. From the Pediatric Cardiology Unit, Buzzi Children’s Hospital, Milan, Italy

2. Fetal Therapy Unit “U. Nicolini”

3. Department of Women, Mother and Neonate, Buzzi Children’s Hospital, University of Milan, Milan, Italy

4. Department of Internal Medicine, University of Pavia, Pavia, Italy

5. Pediatric Department, Buzzi Children’s Hospital, Milan, Italy

6. Department of Medical Biotechnology and Translational Medicine, University of Milan, Segrate, Italy

7. Department of Biomedical and Clinical Science, University of Milan, Milan, Italy

8. Division of Neonatology, Buzzi Children’s Hospital, Milan, Italy; and

9. Immuno-Allergology Laboratory, Clinical Chemistry Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Abstract

We report the first case of significant fetal myocardial involvement associated with maternal SARS-CoV-2 infection, in which restoration of cardiac function at birth was noted. The demonstration of previous infection was supported by the quantification of humoral response in child and mother, in particular the presence of anti-N antibodies and through the detection of specific antibodies against the BA.4/5 variant.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Microbiology (medical),Pediatrics, Perinatology and Child Health

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