U73122, an Aminosteroid Phospholipase C Inhibitor, Is a Potent Inhibitor of Cardiac Phospholipase D by a PIP2-Dependent Mechanism

Author:

Burgdorf Christof,Schäfer Ulrich,Richardt Gert,Kurz Thomas

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Pharmacology

Reference25 articles.

1. Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness.;Smith;J Pharmacol Exp Ther,1990

2. Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.;Bleasdale;J Pharmacol Exp Ther,1990

3. The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell.;Muto;J Pharmacol Exp Ther,1997

4. Phospholipase C inhibitor, U73122, releases intracellular Ca2+, potentiates Ins(1,4,5)P3-mediated Ca2+ release and directly activates ion channels in mouse pancreatic acinar cells.;Mogami;Biochem J,1997

5. The aminosteroid phospholipase C antagonist U-73122 (1-[6-[[17-{beta}-3-Methoxyestra-1,3,5(10)-trien-17yl]amino]hexyl]-1H-pyrrole-2,5-dione) potently inhibits human 5-lipoxygenase in vivo and in vitro.;Feisst;Mol Pharmacol,2005

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