Normal Pressure Hydrocephalus and Cerebral Blood Flow: A PET Study of Baseline Values-Reference-Cited by-同舟云学术

Normal Pressure Hydrocephalus and Cerebral Blood Flow: A PET Study of Baseline Values

Published:2004-01 Issue:1 Volume:24 Page:17-23
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Owler Brian K.¹²³,Momjian Shahan¹²,Czosnyka Zofia¹,Czosnyka Marek¹,Péna Alonso¹,Harris Neil G.²,Smielewski Piotr¹²,Fryer Tim⁴,Donovan Tim⁴,Coles Jonathon⁴,Carpenter Adrian⁴,Pickard John D.¹²

Affiliation:

1. Academic Neurosurgery Unit, Addenbrooke's Hospital, Cambridge, UK

2. Brain Repair Center, University of Cambridge, Cambridge, UK

3. Department of Surgery, University of Sydney, Sydney, Australia

4. Wolfson Brain Imaging Center, University of Cambridge, Cambridge, UK

Abstract

Regional cerebral blood flow (CBF) was studied with O15-water positron emission tomography and anatomic region-of-interest analysis on coregistered magnetic resonance in patients with idiopathic (n = 12) and secondary (n = 5) normal pressure hydrocephalus (NPH). Mean CBF was compared with values obtained from healthy volunteers (n = 12) and with clinical parameters. Mean CBF was significantly decreased in the cerebrum and cerebellum of patients with NPH. The regional analysis demonstrated that CBF was reduced in the basal ganglia and the thalamus but not in white matter regions. The results suggest that the role of the basal ganglia and thalamus in NPH may be more prominent than currently appreciated. The implications for theories regarding the pathogenesis of NPH are discussed.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1097/01.WCB.0000093326.88757.49

Reference39 articles.

1. The Dutch Normal-Pressure Hydrocephalus Study

2. Risk factors for the syndrome of ventricular enlargement with gait apraxia (idiopathic normal pressure hydrocephalus): a case-control study.

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