Autoimmune hepatitis recurrence after liver transplantation: “Les jeux sont faits”-Reference-Cited by-同舟云学术

Autoimmune hepatitis recurrence after liver transplantation: “Les jeux sont faits”

Published:2023-10-04 Issue: Volume: Page:
ISSN:1527-6465
Container-title:Liver Transplantation
language:en
Short-container-title:

Author:

Chouik Yasmina¹²,Corpechot Christophe³,Francoz Claire⁴,De Martin Eleonora⁵,Guillaud Olivier¹,Abergel Armand⁶,Altieri Mario⁷,Barbier Louise⁸,Besch Camille⁹,Chazouillères Olivier³^ORCID,Conti Filomena¹⁰,Dharancy Sébastien¹¹^ORCID,Durand François⁴,Duvoux Christophe¹²,Gugenheim Jean¹³,Hardwigsen Jean¹⁴,Hilleret Marie-Noëlle¹⁵,Houssel-Debry Pauline¹⁶,Kamar Nassim¹⁷,Minello Anne¹⁸,Neau-Cransac Martine¹⁹,Pageaux Georges-Philippe²⁰,Radenne Sylvie²,Roux Olivier⁴,Saliba Faouzi⁵,Samuel Didier⁵,Vanlemmens Claire²¹,Woehl-Jaegle Marie-Lorraine⁸,Leroy Vincent¹⁵,Duclos-Vallée Jean-Charles⁵^ORCID,Dumortier Jérôme¹^ORCID

Affiliation:

1. Hospices civils de Lyon, Hôpital Edouard Herriot, Service d’Hépato-Gastroentérologie, and Université Claude Bernard Lyon 1, Lyon, France

2. Hospices civils de Lyon, Hôpital de la Croix Rousse, Service d’Hépato-Gastroentérologie, Lyon, France

3. Hôpital Saint-Antoine, Centre de référence des maladies inflammatoires des voies biliaires et des hépatites auto-immunes, Filière de santé FILFOIE, Assistance Publique – Hôpitaux de Paris (AP-HP), INSERM UMRS 938, Centre de Recherche Saint-Antoine, Sorbonne Université, Paris

4. APHP, Hôpital Beaujon, Service d’Hépatologie et Transplantation Hépatique - Université Paris Diderot - INSERM U1149, Clichy

5. AP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, Inserm Unité 1193, Université Paris-Saclay, FHU Hépatinov, Centre de Référence Maladies Inflammatoires des Voies Biliaires et Hépatites Auto-immunes, Villejuif

6. CHU Estaing, Médecine digestive, Institut Pascal, UMR 6602 UCA CNRS SIGMA, Clermont-Ferrand

7. Hôpital Côte de Nacre, Service d’Hépato-Gastroentérologie, Nutrition et Oncologie Digestive, Caen

8. CHU Tours, Hôpital Trousseau Service de chirurgie digestive, oncologique et endocrinienne, Transplantation hépatique, Tours

9. CHRU Hautepierre, Service de chirurgie hépato-bilio-pancréatique et transplantation hépatique, Strasbourg

10. Service de Chirurgie Digestive et Hépato-Biliaire, Transplantation Hépatique, AP-HP Hôpital Pitié Salpêtrière, Paris

11. CHRU Lille, Hôpital Claude Huriez, Service d’hépatologie, Lille

12. APHP, Hôpital Henri Mondor, Service d’hépatologie, Créteil

13. Hôpital universitaire de Nice, service de Chirurgie Digestive et de Transplantation Hépatique - Université de Nice-Sophia-Antipolis, Nice

14. APHM, Hôpital La Timone, Service chirurgie générale et transplantation hépatique Marseille

15. CHU Grenoble-Alpes, Service d’hépato-gastroentérologie- INSERM U1209-Université Grenoble-Alpes, La Tronche

16. Hôpital Universitaire de Pontchaillou, Service d’Hépatologie et Transplantation hépatique, Rennes

17. CHU Rangueil, Département de Néphrologie et Transplantation d’Organes, Toulouse

18. CHU Dijon, Service d’Hépato-gastroentérologie et oncologie digestive, Inserm EPICAD LNC-UMR1231, Université de Bourgogne-Franche Comté, Dijon

19. CHU de Bordeaux, Hôpital Haut Lévêque, Service de Chirurgie hépatobiliaire et de transplantation hépatique, Bordeaux

20. CHU Saint Eloi, Département d’hépatologie et transplantation hépatique, Montpellier

21. Hôpital Jean Minjoz, Service d’Hépatologie et Soins Intensifs Digestifs, Besançon, France

Abstract

Autoimmune hepatitis (AIH) may recur after liver transplantation (LT). The aims of this study were to evaluate the incidence and risk factors for recurrent autoimmune hepatitis (rAIH). A multicenter retrospective French nationwide study, including all patients aged ≥16 transplanted for AIH, with at least 1 liver biopsy 1 year after LT, was conducted between 1985 and 2018. Risk factors for rAIH were identified using a multivariate Cox regression model. Three hundred and forty-four patients were included (78.8% women) with a median age at LT of 43.6 years. Seventy-six patients (22.1%) developed recurrence in a median time of 53.6 months (IQR, 14.1–93.2). Actuarial risk for developing rAIH was 41.3% 20 years after LT. In multivariate analysis, the strongest risk factor for rAIH was cytomegalovirus D+/R− mismatch status (HR=2.0; 95% CI: 1.1–3.6; p=0.03), followed by associated autoimmune condition. Twenty-one patients (27.6% of rAIH patients) developed liver graft cirrhosis after rAIH. Independent risk factors for these severe forms of rAIH were young age at LT, IgG levels >20.7 g/L, and LT in the context of (sub)fulminant hepatitis. Immunosuppression, especially long-term maintenance of corticosteroid therapy, was not significantly associated with rAIH. Recurrence of AIH after LT is frequent and may lead to graft loss. Recurrence is more frequent in young patients with active disease at the time of LT, yet systematic corticosteroid therapy does not prevent it.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Transplantation,Hepatology,Surgery

Reference42 articles.

1. EASL Clinical Practice Guidelines: autoimmune hepatitis;J Hepatol,2015

2. Second-line and third-line therapy for autoimmune hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group;Lohse;J Hepatol,2020

3. Long-term outcomes of patients with autoimmune hepatitis managed at a nontransplant center;Hoeroldt;Gastroenterology,2011

4. Twenty-year comparative analysis of patients with autoimmune liver diseases on transplant waitlists;Webb;Clin Gastroenterol Hepatol,2018

5. Outcome of autoimmune hepatitis after liver transplantation;Prados;Transplantation,1998

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recurrence of autoimmune liver diseases after liver transplantation: Review and expert opinion statement;Liver Transplantation;2024-06-11