Essential Fatty Acid Deficiency Is Common After Total Pancreatectomy and Islet Autotransplantation

Author:

Downs Elissa M.1,Hodges James S.2,Trikudanathan Guru3,Freeman Martin L.3,Chinnakotla Srinath4,Kirchner Varvara5,Pruett Timothy L.4,Beilman Gregory6,Schwarzenberg Sarah Jane1,Bellin Melena D.7

Affiliation:

1. Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition; University of Minnesota, Minneapolis, MN

2. School of Public Health, Division of Biostatistics; University of Minnesota, Minneapolis, MN

3. Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition; University of Minnesota, Minneapolis, MN

4. Department of Surgery, Division of Transplantation; University of Minnesota, Minneapolis, MN

5. Department of Surgery, Division of Transplantation; Stanford University, Stanford, CA

6. Department of Surgery; University of Minnesota, Minneapolis, MN

7. Department of Pediatrics, Division of Endocrinology; Department of Surgery; University of Minnesota, Minneapolis, MN.

Abstract

Objectives Total pancreatectomy and islet autotransplantation (TPIAT) for pancreatitis may induce risk for essential fatty acid deficiency (EFAD) due to exocrine pancreatic insufficiency and intestinal alterations. The prevalence of EFAD post-TPIAT is currently unknown. Methods We abstracted essential fatty acid (EFA) profiles (n = 332 samples) for 197 TPIAT recipients (72% adult, 33% male). Statistical analyses determined the prevalence of, and associations with, EFAD post-operatively. EFAD was defined as a Triene-to-Tetraene ratio ≥0.05 if <18 years old, or ≥0.038 if ≥18 years old. Results Prevalence of EFAD was 33%, 49%, and 53.5% at 1, 2, and ≥3 years. At 1-year post-TPIAT, older age at transplant (P = 0.03), being an adult versus a child (P = 0.0024), and obstructive etiology (P = 0.0004) were significant predictors of EFAD. Only 6% of children had EFAD 1-year post-TPIAT versus 46% of adults. The alpha-linolenic acid levels were lower with lower body mass index at transplant (P = 0.011). EFAD was associated with the presence of other intestinal diseases (P < 0.0001). Conclusions One-third of individuals had EFAD 1-year post-TPIAT, highlighting the need for systematic monitoring. Older age at transplant increased risk and adults were more affected than children. Other diagnoses affecting intestinal health may further increase risk for EFAD.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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