Efficacy and safety of bilastine vs. levocetirizine for the treatment of chronic idiopathic urticaria: A multicenter, double-blind, double-dummy, phase III, non-inferiority, randomized clinical trial

Author:

Chen Xue1,Han Xiuping2,Cheng Bo3,Li Hui4,Liu Lingling5,Geng Songmei6,Li Linfeng7,Li Jie8,Guo Qing9,Zhang Guoyi10,Fang Hong11,Zhang Jianzhong1

Affiliation:

1. Department of Dermatology, Peking University People’s Hospital, Beijing 100044, China

2. Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110055, China

3. Department of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350004, China

4. Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

5. Department of Dermatology, Peking University First Hospital, Beijing 100034, China

6. Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University (Xibei Hospital), Xi’an, Shaanxi 710006, China

7. Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

8. Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China

9. Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China

10. Department of Dermatology, Hospital for Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, Jiangsu 210042, China

11. Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China

Publisher

Ovid Technologies (Wolters Kluwer Health)

Reference6 articles.

1. Epidemiology of urticaria in China: a population-based study;Li;Chin Med J,2022

2. Efficacy of oral bilastine in comparison with levocetirizine in allergic rhinitis – A randomised clinical study;Vanitha;J Clin Diag Res,2021

3. Treatment of allergic rhinitis and urticaria: A review of the newest antihistamine drug bilastine;Wang;Ther Clin Risk Manag,2016

4. Effectiveness, safety, and tolerability of bilastine 20 mg vs. levocetirizine 5 mg for the treatment of chronic spontaneous urticaria: A double-blind, parallel group, randomized controlled trial;Podder;Dermatol Ther,2020

5. Effect of bilastine on chronic urticaria: A systematic review and meta-analysis;Xue;Int Arch Allergy Immunol,2023

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