Recent advances in immunomodulators for atopic dermatitis

Author:

Yim Hyun J.1,Jean Tiffany2,Ong Peck Y.34

Affiliation:

1. Department of Internal Medicine

2. Department of Allergy, Asthma, & Clinical Immunology, Kaiser Los Angeles Medical Center, Los Angeles

3. Division of Clinical Immunology and Allergy, Children's Hospital Los Angeles

4. Department of Pediatrics, University of Southern California, Los Angeles, California, USA

Abstract

Purpose of review Conventional treatments of atopic dermatitis have been inadequate, especially in patients with moderate-to-severe disease. Recent findings In the past 5 years, four immunomodulators have been approved for the treatment of atopic dermatitis in children. These include dupilumab, ruxolitinib, upadacitinib, and abrocitinib. The review summarizes the pivotal phase 3 trials of these medications. Summary The newer immunomodulators have transformed the treatment of atopic dermatitis, particularly in patients with moderate-to-severe disease. Dupilumab targets IL-4 and IL-13, which are the main causes of allergic inflammation, resulting in great efficacy and few side effects. Upadacitinib and abrocitinib are alternative systemic medications for adolescents who have failed or are unable to tolerate dupilumab. Ruxolitinib cream is the latest addition to the current topical therapy. It is indicated for children 12 years and older with mild-to-moderate atopic dermatitis. Further studies are needed to confirm its safety and efficacy for younger children and for patients with more severe disease.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Pediatrics, Perinatology and Child Health

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