Relationship between the tau protein and choroid plexus volume in Alzheimer’s disease

Author:

Ota Miho12,Sato Noriko1,Nakaya Moto13,Shigemoto Yoko1,Kimura Yukio1,Chiba Emiko1,Yokoi Yuma45,Tsukamoto Tadashi6,Matsuda Hiroshi17

Affiliation:

1. Department of Radiology, National Center of Neurology and Psychiatry, Kodaira, Tokyo

2. Department of Neuropsychiatry, University of Tsukuba, Tsukuba, Ibaraki

3. Department of Radiology, Graduate School of Medicine, University of Tokyo, Bunkyo-ku

4. Department of Psychiatry, National Center of Neurology and Psychiatry

5. Department of Educational Promotion, Clinical Research & Education Promotion Division, National Center of Neurology and Psychiatry

6. Department of Neurology, National Center of Neurology and Psychiatry, Kodaira, Tokyo and

7. Department of Biofunctional Imaging, Fukushima Medical University, Fukushima City, Fukushima, Japan

Abstract

Tau protein accumulation in the brain is thought to be one of the causes of Alzheimer’s disease (AD). Recent studies found that the choroid plexus (CP) has a role in β-amyloid and tau protein clearance in the brain. We evaluated the relationships between CP volume and the ß-amyloid and tau protein depositions. Participants were 20 patients with AD and 35 healthy subjects who underwent MRI and PET scanning using the ß-amyloid tracer 11C-PiB and the tau/inflammatory tracer 18F-THK5351. We computed the volume of the CP and estimated the relationships between the CP volume and ß-amyloid and tau protein/inflammatory deposition by Spearman’s correlation test. The CP volume was significantly positively correlated with both the standardized uptake value ratio (SUVR) of 11C-PiB and the SUVR of 18F-THK5351 in all participants. The CP volume was also significantly positively correlated with the SUVR of 18F-THK5351in patients with AD. Our data suggested that the volume of the CP was a good biomarker for the evaluation of tau deposition and neuroinflammation.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Neuroscience

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