Deficits in our understanding of natural killer cell development in mouse and human

Author:

Schorr Christopher12,Krishnan Maya Shraddha13,Capitano Maegan13

Affiliation:

1. Indiana University School of Medicine, Indianapolis

2. Weldon School of Biomedical Engineering, Purdue University, West Lafayette

3. Department of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA

Abstract

Purpose of review Natural killer (NK) cells are a type of immune cell that play a crucial role in the defense against cancer and viral infections. The development and maturation of NK cells is a complex process, involving the coordination of various signaling pathways, transcription factors, and epigenetic modifications. In recent years, there has been a growing interest in studying the development of NK cells. In this review, we discuss the field's current understanding of the journey a hematopoietic stem cell takes to become a fully mature NK cell and detail the sequential steps and regulation of conventional NK leukopoiesis in both mice and humans. Recent findings Recent studies have highlighted the significance of defining NK development stages. Several groups report differing schema to identify NK cell development and new findings demonstrate novel ways to classify NK cells. Further investigation of NK cell biology and development is needed, as multiomic analysis reveals a large diversity in NK cell development pathways. Summary We provide an overview of current knowledge on the development of NK cells, including the various stages of differentiation, the regulation of development, and the maturation of NK cells in both mice and humans. A deeper understanding of NK cell development has the potential to provide insights into new therapeutic strategies for the treatment of diseases such as cancer and viral infections.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Hematology

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