Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro

Author:

Tanimoto Keiji,Kaneyasu Mika,Shimokuni Tatsushi,Hiyama Keiko,Nishiyama Masahiko

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Genetics (clinical),Genetics,Molecular Biology,Molecular Medicine,General Pharmacology, Toxicology and Pharmaceutics

Reference16 articles.

1. The mammalian carboxylesterases: from molecules to functions;Satoh;Annu Rev Pharmacol Toxicol,1998

2. Enzyme-catalyzed activation of anticancer prodrugs;Rooseboom;Pharmacol Rev,2004

3. Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis;Sanghani;Clin Cancer Res,2003

4. Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan;Xu;Clin Cancer Res,2002

5. Reversal of CPT-11 resistance of lung cancer cells by adenovirus-mediated gene transfer of human carboxylesterase cDNA;Kojima;Cancer Res,1998

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