Cognitive function and bladder health among midlife adult women in the Coronary Artery Risk Development in Young Adults (CARDIA) study

Author:

Brady Sonya S.1ORCID,Arguedas Andrés2,Huling Jared D.2,Hellemann Gerhard3,Yaffe Kristine,Lewis Cora E.4,Fok Cynthia S.5,Van Den Eeden Stephen K.,Markland Alayne D.

Affiliation:

1. Program in Health Disparities Research, Department of Family Medicine and Community Health, University of Minnesota Medical School, Minneapolis, MN

2. Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN

3. Department of Biostatistics, University of Alabama at Birmingham School of Public Health, Birmingham, AL

4. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL

5. Department of Urology, University of Minnesota Medical School, Minneapolis, MN

Abstract

Abstract Objective The aim of this study was to examine whether different aspects of women's cognitive function are associated with lower urinary tract symptoms (LUTS) and their impact. Methods In 2010–2011, women aged 42 to 57 years in the Coronary Artery Risk Development in Young Adults study completed different tests of cognitive function, including the Digit Symbol Substitution Test, Rey Auditory Verbal Learning Test, and Stroop test. Two years later, data on LUTS and their impact were collected. LUTS/impact, a four-level composite variable ranging from bladder health to mild, moderate, and severe LUTS/impact, was regressed on each cognitive test separately, as well as a cognitive function composite variable. The analytic sample was composed of 1,021 women with complete data. Results When adjusting for sociodemographic variables (age, race, education) and gynecologic/obstetric variables (parity, menopausal status, hysterectomy, hormonal use), better performance on the cognitive function composite and Digit Symbol Substitution Test were both associated with lower odds of membership to a more severe LUTS/impact category (odds ratio, 0.90 [95% confidence interval, 0.83-0.98] and 0.89 [95% confidence interval, 0.82-0.97], respectively). These associations became nonsignificant when additionally adjusting for mechanisms that might explain an association between cognitive function and LUTS/impact, including health behaviors and health conditions that may covary with cerebral and peripheral vascular health and cognitive function. Conclusions In this sample of midlife adult women, a modest association was found between better cognitive function and lower likelihood of LUTS/impact. Longitudinal studies are needed to further investigate the association between cognitive function and LUTS/impact, as well as potential explanatory mechanisms, particularly as women age and cognitive function varies to a greater degree.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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1. Mind over bladder;Menopause;2024-07-02

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