Brincidofovir Is Not a Substrate for the Human Organic Anion Transporter 1: A Mechanistic Explanation for the Lack of Nephrotoxicity Observed in Clinical Studies

Author:

Tippin Timothy K.,Morrison Marion E.,Brundage Thomas M.,Momméja-Marin Hervé

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Pharmacology (medical),Pharmacology

Reference26 articles.

1. The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1;Cihlar;Mol Pharmacol.,1999

2. Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs;Cihlar;Nucleosides Nucleotides Nucleic Acids.,2001

3. Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1;Ho;J Am Soc Nephrol.,2000

4. Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys;Lacy;Toxicol Sci.,1998

5. Organic anion transporter (Slc22a) family members as mediators of toxicity;Sweet;Toxicol Appl Pharmacol.,2005

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