Poisoning by butylated hydroxytoluene quinone methide acting as a superwarfarin: first reported case in humans-Reference-Cited by-同舟云学术

Poisoning by butylated hydroxytoluene quinone methide acting as a superwarfarin: first reported case in humans

Published:2024-05-09 Issue:5 Volume:35 Page:279-281
ISSN:0957-5235
Container-title:Blood Coagulation & Fibrinolysis
language:en
Short-container-title:

Author:

Hindilerden Fehmi¹,Aksoy Elif¹,Öztürkmen Asli Yüksel¹,Türker Gamze¹,Gültürk Emine¹,Hançer Veysel Sabri²,Mercan Selda³

Affiliation:

1. Division of Hematology, Department of Internal Medicine, Hamidiye Faculty of Medicine, University of Health Sciences

2. Department of Medical Biology, Faculty of Medicine, Istinye University

3. Department of Science, Institute of Forensic Sciences and Legal Medicine, İstanbul University-Cerrahpaşa, Istanbul, Turkey

Abstract

Superwarfarins are anticoagulant rodenticides nearly 100-fold potent than the parent compound. Since their development, accidental and intentional cases of superwarfarin poisoning have been reported. We report the first human case of poisoning by butylated hydroxytoluene (BHT) quinone methide acting as a superwarfarin otherwise reported to be a well tolerated food additive and preservative and used as an antioxidant, stabilizer, anti-skinning agent in various industries. We aim to highlight the possible underlying cause of this previously unreported and potentially lethal BHT-related complication in the human.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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