Simultaneous thoracic and abdominal donation after circulatory death organ recovery: the abdominal surgeon's perspective

Author:

Thiessen Carrie1,Wisel Steven A.2,Roll Garrett R.3

Affiliation:

1. Division of Transplantation, University of Wisconsin, Madison, Wisconsin

2. Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles

3. Division of Transplantation, University of California, San Francisco, San Francisco, California, USA

Abstract

Purpose of the review To summarize the international experience with heart-liver (joint) donation after circulatory death (DCD) procurements and to explore the technical challenges in joint abdominal and thoracic DCD procurement. Recent findings Following completion of the Donors After Circulatory Death Heart Trial in the US, combined thoracic and abdominal DCD is poised to become the standard of care, expanding access to life-saving heart and lung allografts. DCD heart procurement relies on collection of donor blood for priming of the normothermic perfusion pump, which delays cooling of abdominal organs and increases risk of ischemic injury. We review the effect of donor ischemia time on abdominal organs, with several proposed technical solutions to optimize transplant outcomes for all organs. Summary The strategies reviewed in this manuscript may inform clinical decision-making, preoperative coordination between thoracic and abdominal procurement teams, and surgical technique for joint DCD procurements. Several approaches to organ procurement organization (OPO) and national policy, as well as future areas of focus for research are proposed.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Transplantation,Immunology and Allergy

Reference39 articles.

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2. University of Pittsburgh Medical Center policy and procedure manual. Management of terminally ill patients who may become organ donors after death;Kennedy Inst Ethics J,1993

3. OPTN/SRTR 2019 annual data report: deceased organ donors;Israni;Am J Transplant,2021

4. Outcome after heart transplantation from donation after circulatory-determined death donors;Messer;J Heart Lung Transplant,2017

5. Outcomes of donation after circulatory death heart transplantation in Australia;Chew;J Am Coll Cardiol,2019

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