Associations of HPV-16 Gene Methylation With Oral HPV-16 Persistence Among a Multinational Sample of Men-Reference-Cited by-同舟云学术

Associations of HPV-16 Gene Methylation With Oral HPV-16 Persistence Among a Multinational Sample of Men

Published:2023-03-22 Issue:7 Volume:50 Page:455-457
ISSN:1537-4521
Container-title:Sexually Transmitted Diseases
language:en
Short-container-title:Sexual Trans Dis

Author:

Islam Jessica Y.¹,Bettampadi Deepti¹,Reich Richard R.²,Nedjai Belinda³,Giuliano Anna R.¹

Affiliation:

1. Center for Immunization and Infection Research in Cancer, Cancer Epidemiology Program

2. Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

3. Center for Cancer Prevention, Queen Mary University of London, London, United Kingdom

Abstract

Abstract Using data from the Human Papillomavirus (HPV) Infection in Men cohort study, we demonstrate HPV-16 methylation associations with persistent oral HPV infection, the obligate precursor to oropharyngeal cancer. Human papillomavirus type 16 persistence was significantly associated with methylation of HPV-16 L2 CpG-4268 (Wilcoxon P = 0.04), and methylation of HPV-16 E2 CpG Pos 4 (Wilcoxon P = 0.04).

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,Dermatology

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