Langerhans Cell Histiocytosis of Bilateral Parotid and Submandibular Glands

Author:

Prakash Sneha1,Shamim Shamim Ahmed1,Bakhshi Sameer2,Pushpam Deepam2,Sharma Aparna2

Affiliation:

1. Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India

2. Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India

Abstract

Abstract Langerhans cell histiocytosis is a disorder of the mononuclear phagocytic system. Virtually any organ can be involved, the bone, skin, lungs, and pituitary gland being the most common. We describe the case of a 30-year-old man who presented with painless neck swelling. 18F-FDG PET/CT showed bilateral bulky parotid and submandibular glands with increased metabolic activity. Histopathology confirmed the diagnosis of Langerhans cell histiocytosis. To our knowledge, there has been no description of 18F-FDG PET/CT findings in Langerhans cell histiocytosis of salivary glands in literature. We aim to aid in the diagnosis and management of this rare presentation.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Radiology, Nuclear Medicine and imaging,General Medicine

Reference8 articles.

1. Langerhans-cell histiocytosis;N Engl J Med,2018

2. Langerhans’ cell histiocytosis in the parotid gland;Ann Clin Lab Sci,2002

3. Langerhans cell histiocytosis presenting as a painless bilateral swelling of the parotid glands;J Pediatr Hematol Oncol,2004

4. Incidental Langerhans cell histiocytosis of the parotid gland resembling marginal zone B-cell lymphoma: a case report;J Oral Pathol Med,2006

5. Swelling of bilateral parotid glands: an unusual symptom of multisystem Langerhans cell histiocytosis;SAGE Open Med Case Rep,2014

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