18F-FDG PET/CT in Pediatric ALK-Positive Histiocytosis With Isolated CNS Involvement-Reference-Cited by-同舟云学术

18F-FDG PET/CT in Pediatric ALK-Positive Histiocytosis With Isolated CNS Involvement

Published:2024-05-31 Issue:10 Volume:49 Page:e506-e508
ISSN:1536-0229
Container-title:Clinical Nuclear Medicine
language:en
Short-container-title:Clin Nucl Med

Author:

Singh Karan¹,London Kevin,Ryan Jessica²,Wright Dale C.,Moghimi Ali

Affiliation:

1. Department of Nuclear Medicine, The Children’s Hospital at Westmead, Sydney Children’s Hospitals Network, Sydney, Australia

2. Cancer Centre for Children, The Children’s Hospital at Westmead, Westmead, Australia

Abstract

Abstract An 11-year-old girl presented with focal impaired awareness seizures. MRI brain demonstrated a T2 hyperintense cortical lesion in the left temporal lobe with surrounding vasogenic edema. 18F-FDG PET/CT was arranged to assess metabolic activity of the cerebral lesion, to screen the whole body for other metabolically active lesions, and to assist biopsy planning. The study demonstrated intensely increased FDG uptake within the left temporal lobe lesion without evidence of hypermetabolic lesions elsewhere on the whole-body acquisition. The brain lesion was excised, and histopathology and molecular testing were consistent with ALK-positive histiocytosis.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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