Monitoring Dual-Cancer Treatment in a Patient With Prostate and Hepatocellular Carcinoma Using Prostate-Specific Membrane Antigen-Directed PET/CT

Author:

Reiter Florian P.,Weich Alexander,Higuchi Takahiro,Serfling Sebastian E.1,Kickuth Ralph2,Werner Rudolf A.

Affiliation:

1. Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany

2. Department of Diagnostic and Interventional Radiology, University Hospital, University of Würzburg, Würzburg, Germany

Abstract

Abstract We report on a 70-year-old man affected with prostate carcinoma (PC) scheduled for prostate-specific membrane antigen (PSMA) PET/CT using 18F-PSMA1007. Because of uptake in the liver and corresponding findings on magnetic resonance, diagnosis of hepatocellular carcinoma (HCC, G1) was established. The patient was then scheduled for antihormonal treatment for PC and locoregional therapy due to HCC. On follow-up PSMA-targeted PET/CT, we observed durable response to PC-associated therapy, whereas hepatic lesions showed progressive disease. As such, we herein report on a dual-cancer targeting molecular imaging strategy to determine disease extent in a patient affected with both PC and HCC, along with potential of monitoring both systemic and locoregional treatment.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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