68Ga-Oxine–Labeled Erythrocytes as a New PET Tracer for the Localization of Gastrointestinal Bleeding
-
Published:2023-12-18
Issue:3
Volume:49
Page:280-282
-
ISSN:1536-0229
-
Container-title:Clinical Nuclear Medicine
-
language:en
-
Short-container-title:Clin Nucl Med
Author:
Leder Theresa,Kühnel Christian,Gröber Sebastian,Drescher Robert,Freesmeyer Martin
Abstract
Abstract
A 69-year-old man presented with recurring drops in hemoglobin levels and suspected gastrointestinal bleeding. Endoscopy did not show a site of bleeding so further examinations became necessary. Scintigraphy and SPECT/CT with 99mTcO4
−–labeled red blood cells were performed without evidence of a hemorrhage. Based on an established protocol for splenic PET/CT, autologous erythrocytes can be labeled with 68Ga-oxine and used as a tracer for the localization of active bleeding sites. In the patient, PET/CT with 68Ga-oxine–labeled undamaged erythrocytes was performed successfully and revealed a hemorrhage of the gastric corpus that was confirmed and treated by endoscopy.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Radiology, Nuclear Medicine and imaging,General Medicine
Reference10 articles.
1. The acute upper gastrointestinal bleed;Surg Clin North Am,2018
2. The role of nuclear medicine in the detection of acute gastrointestinal bleeding;Semin Nucl Med,2006
3. Endoscopy, angiography, surgery: diagnostic and therapeutic algorithms for diverticular bleeding [in German];Chirurg,2019
4. Evaluation of gastrointestinal bleeding by red blood cells labeled in vivo with technetium-99m;J Nucl Med,1979
5. PET versus SPECT: strengths, limitations and challenges;Nucl Med Commun,2008